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2024

DNA methylation controls stemness of astrocytes in health and ischaemia
Graphical Abstract: Aging
  • Lukas P. M. Kremer, Santiago Cerrizuela, Hadil El-Sammak, Mohammad Eid Al Shukairi, Tobias Ellinger, Jannes Straub, Aylin Korkmaz, Katrin Volk, Jan Brunken, Susanne Kleber, Simon Anders, Ana Martin-Villalba
  • Journal: Nature: 634, 415–423
  • Date: 2024 September 4
  • DOI: 10.1038/s41586-024-07898-9

Analyzing single-cell bisulfite sequencing data with MethSCAn
Graphical Abstract: Aging
  • Lukas P. M. Kremer, Martina M. Braun, Svetlana Ovchinnikova, Leonie Küchenhoff, Santiago Cerrizuela, Ana Martin-Villalba, Simon Anders
  • Journal: Nature Methods: 21, 1616–1623
  • Date: 2024 July 31
  • DOI: 10.1038/s41592-024-02347-x

Cancer Evolution: A Multifaceted Affair
Graphical Abstract: Aging
  • Giovanni Ciriello, Luca Magnani, Sarah J. Aitken, Leila Akkari, Sam Behjati, Douglas Hanahan, Dan A. Landau, Nuria Lopez-Bigas, Darío G. Lupiáñez, Jean-Christophe Marine, Ana Martin-Villalba, Gioacchino Natoli, Anna C. Obenauf, Elisa Oricchio, Paola Scaffidi, Andrea Sottoriva, Alexander Swarbrick, Giovanni Tonon, Sakari Vanharanta, Johannes Zuber
  • Journal: Aging: 14 (1), 36-48
  • Date: 2024 January 12
  • DOI: 10.1158/2159-8290.CD-23-0530

2023

Identification of astrocyte-driven pseudolineages reveals clinical stratification and therapeutic targets in Glioblastoma
Graphical Abstract: Aging
  • Leo Carl Foerster, Oguzhan Kaya, Valentin Wüst, Milica Bekavac, Kevin Chris Ziegler, Vuslat Akcay, Nina Stinchcombe, Noelia Gesteira Perez, Xiujian Ma, Ahmed Sadik, Phuong Uyen Le, Kevin Petrecca, Christiane Opitz, Haikun Liu, Christian Rainer Wirtz, Simon Anders, Angela Goncalves, Ana Martin-Villalba
  • Journal: bioRxiv
  • Date: 2023 September 17
  • DOI: 10.1101/2023.09.15.557713

Mathematics of neural stem cells: Linking data and processes
Graphical Abstract: Aging
  • Diana-Patricia Danciu, Jooa Hooli, Ana Martin-Villalba, Anna Marciniak-Czochra
  • Journal: Cells & Development: 174,
  • Date: 2023 June
  • DOI: 10.1016/j.cdev.2023.203849

Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle
Graphical Abstract: Aging
  • Damian Carvajal Ibañez, Maxim Skabkin, Jooa Hooli, Santiago Cerrizuela, Manuel Göpferich, Adrien Jolly, Katrin Volk, Marc Zumwinkel, Matilde Bertolini, Gianluca Figlia, Thomas Höfer, Guenter Kramer, Simon Anders, Aurelio A Teleman, Anna Marciniak‐Czochra, Ana Martin‐Villalba
  • Journal: EMBO Molecular Medicine: 15, 4
  • Date: 2023 January 13
  • DOI: 10.15252/emmm.202216434

2022

Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain
Graphical Abstract: Aging
  • Lukas PM Kremer, Santiago Cerrizuela, Mohammad Eid Al Shukairi, Tobias Ellinger, Jannes Straub, Sascha Dehler, Aylin Korkmaz, Dieter Weichenhan, Christoph Plass, Simon Anders, Ana Martin-Villalba
  • Journal: bioRxiv
  • Date: 2022 June 14
  • DOI: 10.1038/s41586-024-07898-9

Analyzing single-cell bisulfite sequencing data with scbs
Graphical Abstract: Aging
  • Lukas P. M. Kremer, Martina M. Braun, Svetlana Ovchinnikova, Leonie Küchenhoff, Santiago Cerrizuela, Ana Martin-Villalba, Simon Anders
  • Journal: bioRxiv
  • Date: 2022 June 17
  • DOI: 10.1038/s41592-024-02347-x

High-throughput scNMT protocol for multiomics profiling of single cells from mouse brain and pancreatic organoids
Graphical Abstract: Aging
  • Santiago Cerrizuela, Oguzhan Kaya, Lukas P.M. Kremer, Andrea Sarvari, Tobias Ellinger, Jannes Straub, Jan Brunken, Andrés Sanz-Morejón, Aylin Korkmaz, Ana Martín-Villalba
  • Journal: STAR Protocols: 3, 3, 101555
  • Date: 2022 September 16
  • DOI: 10.1016/j.xpro.2022.101555

2021

High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone
Graphical Abstract: Aging
  • Lukas P.M. Kremer, Santiago Cerrizuela, Sascha Dehler, Thomas Stiehl, Jonas Weinmann, Heike Abendroth, Susanne Kleber, Alexander Laure, Jihad El Andari, Simon Anders, Anna Marciniak-Czochra, Dirk Grimm, Ana Martin-Villalba
  • Journal: Molecular Therapy: 23, 35-50
  • Date: 2021 December 10
  • DOI: 10.1016/j.omtm.2021.07.001

2020

Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1
Graphical Abstract: Aging
  • Jesús Romero-Pozuelo, Gianluca Figlia, Oguzhan Kaya, Ana Martin-Villalba, Aurelio A. Teleman
  • Journal: Cell Reports: 31, 2
  • Date: 2020 April 2020
  • DOI: 10.1016/j.celrep.2020.03.068

2019

Latest advances in aging research and drug discovery
Graphical Abstract: Aging
  • Bakula, D., Ablasser, A., Aguzzi, A., Antebi, A., Barzilai, N., Bittner, M.-I., Jensen, M.B., Calkhoven, C.F., Chen, D., Grey, A.D.N.J.d., Feige, J.N., Georgievskaya, A., Gladyshev, V.N., Golato, t., Gudkov, A.V., Hoppe, T., Kaeberlein, M., Katajisto, P., Kennedy, B.K., Lal, U., Martin-Villalba, A., Moskalev, A.A., Ozerov, I., Petr, M.A., Reason, et al.
  • Journal: Aging: 11, 9971-9981
  • Date: 2019 November 21
  • DOI: 10.18632/aging.102487

Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain
Graphical Abstract: EMBO
  • Lepko, T., Pusch, M., Müller, T., Schulte, D., Ehses, J., Kiebler, M., Hasler, J., Huttner, H.B., Vandenbroucke, R.E., Vandendriessche, C., Modic, M., Martin-Villalba, A., Zhao, S., Llorens-Bobadilla, E., Schneider, A., Fischer, A., Breunig, C.T., Stricker, S.H., Götz, M., Ninkovic, J.
  • Journal: EMBO Journal: 38(17), e100481
  • Date: 2019 July 15
  • DOI: 10.15252/embj.2018100481

3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival
Graphical Abstract: Cell
  • Gülcüler Balta GS, Monzel C, Kleber S, Beaudouin J, Balta E, Kaindl T, Chen S, Gao L, Thiemann M, Wirtz CR, Samstag Y,Tanaka M, Martin-Villalba
  • Journal: Cell Reports: 176(6), 1407-1419
  • Date: 2019 Nov 19
  • DOI: 10.1016/j.celrep.2019.10.054

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Graphical Abstract: Cell
  • Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A
  • Journal: Cell: 176(6), 1407-1419
  • Date: 2019 Feb 22
  • DOI: 10.1016/j.cell.2019.01.040

Onset of differentiation is posttranscriptionally controlled in adult neural stem cells
Cover of the Journal: Nature
  • Baser A, Dang Y, Skabkin M, Guelcueler Balta G, Kalamakis G, Kleber S, Goepferich M, Carvajal Ibañez D, Schefzik R, Santos Lopez A, Llorens Bobadilla E, Schultz C, Fischer B, Martin-Villalba A
  • Journal: Nature: 566(7742), 100
  • Date: 2019 Jan 30
  • DOI: 10.1038/s41586-019-0888-x

2018

Cell-cell contact dictates life or death decisions following CD95 activation in cancer
Cover of the Journal: bioRxiv
  • Guelcueler Balta G, Monzel C, Kleber S, Beaudouin J, Kaindl T, Thiemann M, Wirtz CR, Tanaka M, Martin-Villalba A
  • Journal: bioRxiv: 308346
  • Date: 2018 Apr 25
  • DOI: 10.1101/308346

An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury
Cover of the Journal: Frontiers in Molecular Neuroscience
  • Dehler S, Pak-Kin Lou W, Gao L, Skabkin M, Dällenbach S, Neumann A and Martin-Villalba A
  • Journal: Frontiers in Molecular Neuroscience 11, Article 443
  • Date: 2018 Dec 11
  • DOI: 10.3389/fnmol.2018.00443

Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1
Cover of the Journal: Frontiers in Molecular Neuroscience
  • Lou WP-K * , Mateos A * , Koch M * , Klussman S, Yang C, Lu N, Kumar S, Limpert S, Göpferich M, Zschaetzsch M, Sliwinski C, Kenzelmann M, Seedorf M, Maillo C, Senis E, Grimm D, Puttagunta R, Mendez R, Liu K, Hassan BA † and Martin-Villalba A †
  • Journal: Frontiers in Molecular Neuroscience 10, Article 445
  • Date: 2018 Jan 12
  • DOI: 10.3389/fnmol.2017.00445
* These authors contributed equally to this work.
† To whom correspondence should be addressed

Revealing age-related changes of adult hippocampal neurogenesis using mathematical models
Cover of the Journal: Development
  • Ziebell F, Dehler S, Martin-Villalba A, Marciniak-Czochra A
  • Journal: Development 145(1):pii: dev153544
  • Date: 2018 Jan 08
  • DOI: 10.1242/dev.153544

2017

Neural Stem Cell Activation and the Role of Protein Synthesis
Cover of the Journal: Brain Plasticity
  • Baser A, Skabkin M, Martin-Villalba A
  • Journal: Brain Plasticity 3(1):27-41
  • Date: 2017 Nov 09
  • DOI: 10.3233/BPL-160038

CNS Macrophages Control Neurovascular Development via CD95L
Cover of the Journal: Cell Reports
  • Chen S, Tisch N, Kegel M, Yerbes R, Hermann R, Hudalla H, Zuliani C, Gülcüler GS, Zwadlo K, von Engelhardt J, Ruiz de Almodóvar C, Martin-Villalba A
  • Journal: Cell Reports 19(7):1378-1393
  • Date: 2017 May 16
  • DOI: 10.1016/j.celrep.2017.04.056

2016

Adult NSC diversity and plasticity: the role of the niche
Cover of the Journal: Current Opinion in Neurobiology
  • Llorens-Bobadilla E, Martin-Villalba A
  • Journal: Current Opinion in Neurobiology 42:68-74
  • Date: 2016 Dec 12
  • DOI: 10.1016/j.conb.2016.11.008

Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex
Cover of the Journal Cell Stem Cell
  • Bifari F *, Decimo I *, Pino A, Llorens-Bobadilla E, Zhao S, Lange C, Panuccio G, Boeckx B, Thienpont B, Vinckier S, Wyns S, Bouché A, Lambrechts D, Giugliano M, Dewerchin M, Martin-Villalba A, Carmeliet P †
  • Journal: Cell Stem Cell 20(3):360–373.
  • Date: 2016 Nov 23
  • DOI: 10.1016/j.stem.2016.10.020
* These authors contributed equally to this work.
† To whom correspondence should be addressed

RNA-seq library preparation from single pancreatic acinar cells
Cover of the Journal
  • Wollny D, Zhao S, Martin-Villalba A
  • Preprint Server: bioRxiv
  • Date: 2016 Nov 04
  • DOI: 10.1101/085696

Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas
Cover of the Journal
  • Wollny D, Zhao S, Everlien I, Lun X, Brunken J, Brüne D, Ziebell F, Tabansky I, Weichert W, Marciniak-Czochra A, Martin-Villalba A
  • Journal: Developmental Cell 39(3)
  • Date: 2016 Nov 07
  • DOI: 10.1016/j.devcel.2016.10.002

Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion
Cover of the eLife Journal
  • Gao L, Gülcüler GS, Golbach L, Block H, Zarbock A, Martin-Villalba A
  • Journal: eLife 5
  • Date: 2016 Oct 20
  • DOI: 10.7554/eLife.18542

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells
  • Drachsler M *, Kleber S *, Mateos A, Volk K, Mohr N, Chen S, Cirovic B, Tüttenberg J, Gieffers C, Sykora J, Wirtz CR, Mueller W, Synowitz M, Martin-Villalba A.
  • Journal: Cell Death & Disease 7 , e2209
  • Date: 2016 Apr 28
  • DOI: 10.1038/cddis.2016.102.
* These authors contributed equally to this work.

2015

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury
Cover of the <!-- name of journal --> Journal
  • Llorens-Bobadilla E, Zhao S, Baser A, Saiz-Castro G, Zwadlo K, Martin-Villalba A
  • Journal: Cell Stem Cell 17(3):329-40
  • Date: 2015 Sep 3 - Epub 2015 Jul 30
  • DOI: 10.1016/j.stem.2015.07.002
To take a look at the data, click here

Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice
Cover of the <!-- name of journal --> Journal
  • Gao L, Brenner D, Llorens-Bobadilla E, Saiz-Castro G, Frank T, Wieghofer P, Hill O, Thiemann M, Karray S, Prinz M, Weishaupt JH, Martin-Villalba A
  • Journal: J Exp Med 212(4)
  • Date: 2015 Mar 16 - [Epub ahead of print]
  • DOI: 10.1084/jem.20132423

CD95 promotes metastatic spread via Sck in pancreatic ductal adenocarcinoma
Cover of the <!-- name of journal --> Journal
  • Teodorczyk M*, Kleber S*, Wollny D*, Sefrin JP, Aykut B, Mateos A, Herhaus P, Sancho-Martinez I, Hill O, Gieffers C, Sykora J, Weichert W, Eisen C, Trumpp A, Sprick MR, Bergmann F, Welsch T, Martin-Villalba A
  • Journal: Cell Death Differ 22(7):1192–1202
  • Date: 2015 Jan 23 - [Epub ahead of print]
  • DOI: 10.1038/cdd.2014.217
* These authors contributed equally to this work.

2014

Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke
Cover of the <!-- name of journal --> Journal
  • Mracsko E, Liesz A, Stojanovic A, Lou WP, Osswald M, Zhou W, Karcher S, Winkler F, Martin-Villalba A, Cerwenka A, Veltkamp R
  • Journal: J Neurosci. 34(50):16784-95
  • Date: 2014 Dec 10
  • DOI: 10.1523/JNEUROSCI.1867-14.2014

Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review
Cover of the <!-- name of journal --> Journal
  • Seib DR, Martin-Villalba A
  • Journal: Gerontology
  • Date: 2014 Nov 29
  • DOI: 10.1159/000368575

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients
Cover of the <!-- name of journal --> Journal
  • Grozdanov V, Bliederhaeuser C, Ruf WP, Roth V, Fundel-Clemens K, Zondler L, Brenner D, Martin-Villalba A, Hengerer B, Kassubek J, Ludolph AC, Weishaupt JH, Danzer KM
  • Journal: Acta Neuropathol 28(5):651-63
  • Date: 2014 Nov - Epub 2014 Oct 5
  • DOI: 10.1007/s00401-014-1345-4

In vivo interrogation of central nervous system translatome by polyribosome fractionation
Cover of the <!-- name of journal --> Journal
  • Lou WP, Baser A, Klußmann S, Martin-Villalba A
  • Journal: J Vis Exp (86)
  • Date: 2014 Apr 30
  • DOI: 10.3791/51255

Mathematical modelling of adult hippocampal neurogenesis: effects of altered stem cell dynamics on cell counts and bromodeoxyuridine-labelled cells
Cover of the <!-- name of journal --> Journal
  • Ziebell F, Martin-Villalba A, Marciniak-Czochra A
  • Journal: J R Soc Interface 11(94):20140144
  • Date: 2014 Mar 5 - Print 2014 May 6
  • DOI: 10.1098/rsif.2014.0144

2013

CD95 in Cancer: Tool or Target?
Cover of the <!-- name of journal --> Journal
  • Martin-Villalba, Ana, Enric Llorens-Bobadilla, and Damian Wollny
  • Journal: Trends in Molecular Medicine
  • Date: 2013 March 26
  • DOI: 10.1016/j.molmed.2013.03.002

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline
Cover of the <!-- name of journal --> Journal
  • Seib, Désirée R M, Nina S Corsini, Kristina Ellwanger, Christian Plaas, Alvaro Mateos, Claudia Pitzer, Christof Niehrs, Tansu Celikel, and Ana Martin-Villalba
  • Journal: Cell Stem Cell 12, no. 2:204–214
  • Date: 2013 Feb 7
  • DOI: 10.1016/j.stem.2012.11.010

2011

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma
Cover of the <!-- name of journal --> Journal
  • Zhang M, Kleber S, Röhrich M, Timke C, Han N, Tuettenberg J, Martin-Villalba A, Debus J, Peschke P, Wirkner U, Lahn M, Huber PE
  • Journal: Cancer Res 71(23):7155-67
  • Date: 2011 Dec 1 - Epub 2011 Oct 17
  • DOI: 10.1158/0008-5472.CAN-11-1212

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat
Cover of the <!-- name of journal --> Journal
  • Milde T, Kleber S, Korshunov A, Witt H, Hielscher T, Koch P, Kopp HG, Jugold M, Deubzer HE, Oehme I, Lodrini M, Gröne HJ, Benner A, Brüstle O, Gilbertson RJ, von Deimling A, Kulozik AE, Pfister SM, Martin-Villalba A, Witt O
  • Journal: Acta Neuropathol 122(5):637-50
  • Date: 2011 Nov - Epub 2011 Aug 24
  • DOI: 10.1007/s00401-011-0866-3

Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis
Cover of the <!-- name of journal --> Journal
  • Ribeiro D, Ellwanger K*, Glagow D*, Theofilopoulos S, Corsini NS, Martin-Villalba A, Niehrs C, Arenas E
  • Journal: PLoS One 6(2):e15786
  • Date: 2011 Feb 11
  • DOI: 10.1371/journal.pone.0015786
* These authors contributed equally to this work.

2010

Integrin Alpha 6: Anchors Away for Glioma Stem Cells
Cover of the <!-- name of journal --> Journal
  • Corsini NS, Martin-Villalba A
  • Journal: Cell Stem Cell 6(5):403-4
  • Date: 2010 May 7
  • DOI: 10.1016/j.stem.2010.04.003

The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury
Cover of the <!-- name of journal --> Journal
  • Pitzer C, Klussmann S, Krüger C, Letellier E, Plaas C, Dittgen T, Kirsch F, Stieltjes B, Weber D, Laage R, Martin-Villalba A, Schneider A
  • Journal: J Neurochem 113(4):930-42
  • Date: 2010 May - Epub 2010 Feb 25
  • DOI: 10.1111/j.1471-4159.2010.06659.x

CD95-Ligand on Peripheral Myeloid Cells Activates Syk Kinase to Trigger Their Recruitment to the Inflammatory Site
Cover of the <!-- name of journal --> Journal
  • Letellier E, Kumar S, Sancho-Martinez I, Krauth S, Funke-Kaiser A, Laudenklos S, Konecki K, Klussmann S, Corsini NS, Kleber S, Drost N, Neumann A, Lévi-Strauss M, Brors B, Gretz N, Edler L, Fischer C, Hill O, Thiemann M, Biglari B, Karray S, Martin-Villalba A
  • Journal: Immunity 32(2):240-252
  • Date: 2010 Feb 26 - Epub 2010 Feb 11
  • DOI: 10.1016/j.immuni.2010.01.011

Sensing invasion: cell surface receptors driving spreading of glioblastoma
Cover of the <!-- name of journal --> Journal
  • Teodorczyk M, Martin-Villalba A
  • Journal: J Cell Physiol 222(1):1-10
  • Date: 2010 Jan
  • DOI: 10.1002/jcp.21901

2008 - 2009

The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair
Cover of the <!-- name of journal --> Journal
  • Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A
  • Journal: Cell Stem Cell 5(2):178-90
  • Date: 2009 Aug 7
  • DOI: 10.1016/j.stem.2009.05.004

Tyrosine phosphorylation and CD95: a FAScinating switch
Cover of the <!-- name of journal --> Journal
  • Sancho-Martinez I, Martin-Villalba A
  • Journal: Cell Cycle 8(6):838-42
  • Date: 2009 Mar 15 - Epub 2009 Mar 22
  • DOI: 10.4161/cc.8.6.7906

TNF-alpha- and TRAIL-resistant glioma cells undergo autophagy-dependent cell death induced by activated microglia
Cover of the <!-- name of journal --> Journal
  • Mora R, Abschuetz A, Kees T, Dokic I, Joschko N, Kleber S, Geibig R, Mosconi E, Zentgraf H, Martin-Villalba A, Régnier-Vigouroux A
  • Journal: Glia 57(5):561-81
  • Date: 2009 Apr 1
  • DOI: 10.1002/glia.20785

2007 - 2008

The Evolution of Our Understanding on Glioma
Cover of the <!-- name of journal --> Journal
  • Martin-Villalba A, Okuducu AF, von Deimling A
  • Journal: Brain Pathol
  • Date: 2008 Mar 26
  • DOI: 10.1111/j.1750-3639.2008.00136.x

Yes and PI3K bind CD95 to signal invasion of glioblastoma
Cover of the <!-- name of journal --> Journal
  • Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W, Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Gröne HJ, Ganten TM, Sültmann H, Tüttenberg J, von Deimling A, Regnier-Vigouroux A, Herold-Mende C, Martin-Villalba A
  • Journal: Cancer Cell 13(3):235-48
  • Date: 2008 Mar
  • DOI: 10.1016/j.ccr.2008.02.003

Spinal cord injuries entering the Fas(t) lane
Cover of the <!-- name of journal --> Journal
  • Letellier E, Martin-Villalba A
  • Journal: Neurosurgery 60(6):N6-7
  • Date: 2007 Jun
  • DOI: 10.1227/01.neu.0000275317.88854.40

2006

Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice
Cover of the <!-- name of journal --> Journal
  • Stieltjes B, Klussmann S, Bock M, Umathum R, Mangalathu J, Letellier E, Rittgen W, Edler L, Krammer PH, Kauczor HU, Martin-Villalba A, Essig M
  • Journal: Magn Reson Med 55(5):1124-31
  • Date: 2006 May
  • DOI: 10.1002/mrm.20888

Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation
Cover of the <!-- name of journal --> Journal
  • Kuhn A, Herrmann M, Kleber S, Beckmann-Welle M, Fehsel K, Martin-Villalba A, Lehmann P, Ruzicka T, Krammer PH, Kolb-Bachofen V
  • Journal: Arthritis Rheum 54(3):939-50
  • Date: 2006 Mar
  • DOI: 10.1002/art.21658

Control of neuronal branching by the death receptor CD95 (Fas/Apo-1)
Cover of the <!-- name of journal --> Journal
  • Zuliani C, Kleber S, Klussmann S, Wenger T, Kenzelmann M, Schreglmann N, Martinez A, del Rio JA, Soriano E, Vodrazka P, Kuner R, Groene HJ, Herr I, Krammer PH, Martin-Villalba A
  • Journal: Cell Death Differ 13(1):31-40
  • Date: 2006 Jan
  • DOI: 10.1038/sj.cdd.4401720

2005

Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth
Cover of the <!-- name of journal --> Journal
  • Jennemann R, Sandhoff R, Wang S, Kiss E, Gretz N, Zuliani C, Martin-Villalba A, Jager R, Schorle H, Kenzelmann M, Bonrouhi M, Wiegandt H, Grone HJ
  • Journal: Proc Natl Acad Sci U S A 30;102(35):12459-64
  • Date: 2005 Aug - Epub 2005 Aug 18
  • DOI: 10.1073/pnas.0500893102

Molecular targets in spinal cord injury
Cover of the <!-- name of journal --> Journal
  • Klussmann S, Martin-Villalba A
  • Journal: J Mol Med 83(9):657-71
  • Date: 2005 Sep - Epub 2005 Aug 2
  • DOI: 10.1007/s00109-005-0663-3

2004

Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4
Cover of the <!-- name of journal --> Journal
  • Schneider A, Laage R, von Ahsen O, Fischer A, Rossner M, Scheek S, Grunewald S, Kuner R, Weber D, Kruger C, Klaussner B, Gotz B, Hiemisch H, Newrzella D, Martin-Villalba A, Bach A, Schwaninger M
  • Journal: J Neurochem 88(5):1114-26
  • Date: 2004 Mar
  • DOI: 10.1046/j.1471-4159.2003.02228.x

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury
Cover of the <!-- name of journal --> Journal
  • Demjen D, Klussmann S, Kleber S, Zuliani C, Stieltjes B, Metzger C, Hirt UA, Walczak H, Falk W, Essig M, Edler L, Krammer PH, Martin-Villalba A
  • Journal: Nat Med 10(4):389-95
  • Date: 2004 Apr - Epub 2004 Mar 7
  • DOI: 10.1038/nm1007

2002

JunB and Bcl-2 overexpression results in protection against cell death of nigral neurons following axotomy
Cover of the <!-- name of journal --> Journal
  • Winter C, Weiss C, Martin-Villalba A, Zimmermann M, Schenkel J
  • Journal: Brain Res Mol Brain Res 104(2):194-202
  • Date: 2002 Aug 15
  • DOI: 10.1016/S0169-328X(02)00378-9

Disruption of CREB function in brain leads to neurodegeneration
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  • Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schutz G
  • Journal: Nat Genet 31(1):47-54.
  • Date: 2002 May - Epub 2002 Apr 22
  • DOI: 10.1038/ng882

1995 - 2001

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke
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  • Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel J, Krammer PH
  • Journal: Cell Death Differ 8(7):679-86
  • Date: 2001 Jul
  • DOI: 10.1038/sj.cdd.4400882

Involvement of CD95/Apo1/Fas in cell death after myocardial ischemia
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  • Jeremias I, Kupatt C, Martin-Villalba A, Habazettl H, Schenkel J, Boekstegers P, Debatin KM
  • Journal: Circulation 102(8):915-20
  • Date: 2000 Aug 22
  • DOI: 10.1161/01.CIR.102.8.915

CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons
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  • Martin-Villalba A*, Herr I*, Jeremias I, Hahne M, Brandt R, Vogel J, Schenkel J, Herdegen T, Debatin KM
  • Journal: J Neurosci 19(10):3809-17
  • Date: 1999 May 15
  • PubMed: 10234013
* These authors contributed equally to this work.

NF-kappaB is activated and promotes cell death in focal cerebral ischemia
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  • Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M
  • Journal: Nat Med 5(5):554-9
  • Date: 1999 May
  • DOI: 10.1038/8432

FK506 prevents stroke-induced generation of ceramide and apoptosis signaling
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  • Herr I, Martin-Villalba A, Kurz E, Roncaioli P, Schenkel J, Cifone MG, Debatin KM
  • Journal: Brain Res 826(2):210-9
  • Date: 1999 May 1
  • DOI: 10.1016/S0006-8993(99)01288-3

Rapid and long-lasting suppression of the ATF-2 transcription factor is a common response to neuronal injury
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  • Martin-Villalba A, Winter C, Brecht S, Buschmann T, Zimmermann M, Herdegen T
  • Journal: Brain Res Mol Brain Res 62(2):158-66
  • Date: 1998 Nov 20
  • DOI: 10.1016/S0169-328X(98)00239-3

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
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  • Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M
  • Journal: J Neurosci 18(14):5124-35
  • Date: 1998 Jul 15
  • PubMed: 9651196

Expression of Jun, Fos, and ATF-2 proteins in axotomized explanted and cultured adult rat dorsal root ganglia
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  • Buschmann T, Martin-Villalba A, Kocsis JD, Waxman SG, Zimmermann M, Herdegen T
  • Journal: Neuroscience 84(1):163-76
  • Date: 1998 May
  • DOI: 10.1016/S0306-4522(97)00487-9

Transection of rat fimbria-fornix induces lasting expression of c-Jun protein in axotomized septal neurons immunonegative for choline acetyltransferase and nitric oxide synthase
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  • Brecht S, Martin-Villalba A, Zuschratter W, Bravo R, Herdegen T
  • Journal: Exp. Neurol 134(1):112-25
  • Date: 1995 Jul
  • DOI: 10.1006/exnr.1995.1042

Molecular Neurobiology, Prof. Dr. Ana Martin-Villalba - 2019